Lynne is best known for as the voice of Cheetara and Wilykit on the TV Show Thundercats!!

She provided the voices of all female characters on the popular 1980s animated series , among the many roles Lipton performed in the show, she voiced Luna of the Lunatacs; Willa, Queen of the Warrior Maidens; the Female Unicorn Guardian; Wilykit; Mandora; and, most importantly, Cheetara (a role she later reprised for an episode of Family Guy).

She was in the Second City company in Chicago in the 1969-70, and The Committee in Los Angeles and San Francisco. She made her Broadway debut standing by for Bernadette Peters in the ill-fated musical of the classic La Strada, choreographed by Alvin Ailey and directed by Alan Schneider. It lasted one performance. Her Broadway credits include the original production of David Rabe's Boom Boom Room at Lincoln Center's Vivian Beaumont, performing the matinees for Madeline Kahn, and Sherlock Holmes with the Royal Shakespeare Company. She won several Cleo awards for her voiceover and animation work. In the mid-1980s, Ad Age dubbed her the Meryl Streep of the microphone.